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Heatmap graphpad5/19/2023 ![]() ![]() Among these tissues, skeletal muscle is the most susceptible to m 6A loss in aging and shows a reduction in the m 6A methyltransferase METT元. ![]() Our data reveal a positive correlation between m 6A modifications and gene expression homeostasis across tissues as well as tissue-type-specific aging-associated m 6A dynamics. Here, we characterize the m 6A epitranscriptome across the liver, heart and skeletal muscle in young and old nonhuman primates. How N 6-methyladenosine (m 6A), the most abundant mRNA modification, contributes to primate tissue homeostasis and physiological aging remains elusive. M 6A epitranscriptomic regulation of tissue homeostasis during primate aging
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